Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2

In response to chromosomal double-strand breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kinase-like protein kinases ATR and ATM (Mec1 and Tel1 in budding yeast). Following DSB formation, Mec1 and Tel1 phosphorylate histone H2A on serine 129 (know...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Tsabar, Michael, Eapen, Vinay V., Mason, Jennifer M., Memisoglu, Gonen, Waterman, David P., Long, Marcus J., Bishop, Douglas K., Haber, James E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538808/
https://ncbi.nlm.nih.gov/pubmed/26019182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv520
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