Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover...

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Main Authors: Verhees, Koen JP, Pansters, Nicholas AM, Baarsma, Hoeke A, Remels, Alexander HV, Haegens, Astrid, de Theije, Chiel C, Schols, Annemie MWJ, Gosens, Reinoud, Langen, Ramon CJ
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176095/
https://ncbi.nlm.nih.gov/pubmed/24180420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-117
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