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Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2. We report here the 3.5-Å resolution crystal structure of the N-terminal domain of the HCV E1 ectodomain, which reveals a co...

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Bibliografske podrobnosti
Main Authors: El Omari, Kamel, Iourin, Oleg, Kadlec, Jan, Sutton, Geoff, Harlos, Karl, Grimes, Jonathan M., Stuart, David I.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175578/
https://ncbi.nlm.nih.gov/pubmed/25224686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5874
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