Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate NLRP3 inflammasomes resulting in podocyte and glomerular injury during hyperhomocysteinemia (hHcys). However, the mechanism by which the inflammasome senses ROS is still unknown in podocytes upon hHcys stimulation. Th...

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Detaylı Bibliyografya
Asıl Yazarlar: Abais, Justine M., Xia, Min, Li, Guangbi, Chen, Yang, Conley, Sabena M., Gehr, Todd W. B., Boini, Krishna M., Li, Pin-Lan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175351/
https://ncbi.nlm.nih.gov/pubmed/25138219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567537
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