IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling

Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop p...

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Detalhes bibliográficos
Main Authors: Kai, Xin, Chellappa, Vasant, Donado, Carlos, Reyon, Deepak, Sekigami, Yurie, Ataca, Dalya, Louissaint, Abner, Mattoo, Hamid, Joung, J. Keith, Pillai, Shiv
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175336/
https://ncbi.nlm.nih.gov/pubmed/25107905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598763
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