IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling

Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop p...

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Autores principales: Kai, Xin, Chellappa, Vasant, Donado, Carlos, Reyon, Deepak, Sekigami, Yurie, Ataca, Dalya, Louissaint, Abner, Mattoo, Hamid, Joung, J. Keith, Pillai, Shiv
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175336/
https://ncbi.nlm.nih.gov/pubmed/25107905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598763
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