Nuclear Factor of Activated T Cells Regulates the Expression of Interleukin-4 in Th2 Cells in an All-or-none Fashion

Th2 memory lymphocytes have imprinted their Il4 genes epigenetically for expression in dependence of T cell receptor restimulation. However, in a given restimulation, not all Th cells with a memory for IL-4 expression express IL-4. Here, we show that in reactivated Th2 cells, the transcription facto...

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Detalhes bibliográficos
Main Authors: Köck, Juliana, Kreher, Stephan, Lehmann, Katrin, Riedel, René, Bardua, Markus, Lischke, Timo, Jargosch, Manja, Haftmann, Claudia, Bendfeldt, Hanna, Hatam, Farahnaz, Mashreghi, Mir-Farzin, Baumgrass, Ria, Radbruch, Andreas, Chang, Hyun-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175318/
https://ncbi.nlm.nih.gov/pubmed/25037220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587865
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