Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow

The bone marrow maintains memory CD4 T cells, which provide memory to systemic antigens. Here we demonstrate that memory CD4 T cells are reactivated by antigen in the bone marrow. In a secondary immune response, antigen-specific T cells of the bone marrow mobilize and aggregate in immune clusters to...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Siracusa, Francesco, McGrath, Mairi A., Maschmeyer, Patrick, Bardua, Markus, Lehmann, Katrin, Heinz, Gitta, Durek, Pawel, Heinrich, Frederik F., Mashreghi, Mir-Farzin, Chang, Hyun-Dong, Tokoyoda, Koji, Radbruch, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819416/
https://ncbi.nlm.nih.gov/pubmed/29358404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715618115
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