Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia

Long-QT syndrome mutations can cause syncope and sudden death by prolonging the cardiac action potential (AP). Ion channels affected by mutations are various, and the influences of cellular calcium cycling on LQTS cardiac events are unknown. To better understand LQTS arrhythmias, we performed curren...

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Autors principals: Spencer, C. Ian, Baba, Shiro, Nakamura, Kenta, Hua, Ethan A., Sears, Marie A.F., Fu, Chi-cheng, Zhang, Jianhua, Balijepalli, Sadguna, Tomoda, Kiichiro, Hayashi, Yohei, Lizarraga, Paweena, Wojciak, Julianne, Scheinman, Melvin M., Aalto-Setälä, Katriina, Makielski, Jonathan C., January, Craig T., Healy, Kevin E., Kamp, Timothy J., Yamanaka, Shinya, Conklin, Bruce R.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175159/
https://ncbi.nlm.nih.gov/pubmed/25254341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.06.003
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