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Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Previously, our group engineered a plant-derived monoclonal antibody (MAb pE16) that efficiently treated West Nile virus (WNV) infection in mice. In this study, we developed a pE16 variant consisting of a single-chain variable fragment (scFv) fused to the heavy chain constant domains (C(H)) of human...

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Bibliografische gegevens
Hoofdauteurs: Lai, Huafang, He, Junyun, Hurtado, Jonathan, Stahnke, Jake, Fuchs, Anja, Mehlhop, Erin, Gorlatov, Sergey, Loos, Andreas, Diamond, Michael S., Chen, Qiang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175135/
https://ncbi.nlm.nih.gov/pubmed/24975464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pbi.12217
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