Generation and Analysis of Novel Plant-Derived Antibody-Based Therapeutic Molecules against West Nile Virus

Previously, our group engineered a plant-derived monoclonal antibody (MAb) (pHu-E16) that efficiently treated West Nile virus (WNV) infection in mice. In this study, we developed several pHu-E16 variants to improve its efficacy. These variants included a single-chain variable fragment (scFv) of pHu-...

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Autores principales: He, Junyun, Lai, Huafang, Engle, Michael, Gorlatov, Sergey, Gruber, Clemens, Steinkellner, Herta, Diamond, Michael S., Chen, Qiang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968140/
https://ncbi.nlm.nih.gov/pubmed/24675995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093541
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