Characterization of a Computationally Designed Water-soluble Human μ Opioid Receptor Variant Using X-ray Structural Information

BACKGROUND: The recent X-ray crystal structure of the murine μ opioid receptor (MUR) allowed us to reengineer a previously designed water-soluble variant of the transmembrane portion of the human MUR (wsMUR-TM). METHODS: The new variant of water soluble MUR (wsMUR-TM_v2) was engineered based upon th...

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Hauptverfasser: Zhao, Xuelian, Perez-Aguilar, Jose Manuel, atsunaga, Felipe, Lerner, Mitchell, Xi, Jin, Selling, Bernard, Johnson, A. T. Charlie, Saven, Jeffery G., Liu, Renyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175066/
https://ncbi.nlm.nih.gov/pubmed/24835677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000308
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