A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor

G-protein-coupled receptors (GPCRs) play essential roles in various physiological processes, and are widely targeted by pharmaceutical drugs. Despite their importance, studying GPCRs has been problematic due to difficulties in isolating large quantities of these membrane proteins in forms that retai...

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Detalhes bibliográficos
Main Authors: Perez-Aguilar, Jose Manuel, Xi, Jin, Matsunaga, Felipe, Cui, Xu, Selling, Bernard, Saven, Jeffery G., Liu, Renyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682944/
https://ncbi.nlm.nih.gov/pubmed/23799068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066009
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