Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)

PURPOSE: To explore the safety and tolerability of combining two epigenetic drugs: decitabine (a DNA methyltransferase inhibitor) and panobinostat (a histone deacetylase inhibitor), with chemotherapy with temozolomide (an alkylating agent). The purpose of such combination is to evaluate the use of e...

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Bibliografiske detaljer
Main Authors: Xia, Chang, Leon-Ferre, Roberto, Laux, Douglas, Deutsch, Jeremy, Smith, Brian J., Frees, Melanie, Milhem, Mohammed
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175037/
https://ncbi.nlm.nih.gov/pubmed/25062770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2501-1
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