Targeting epigenetics for treatment of BRAF mutated metastatic melanoma with decitabine in combination with vemurafenib: A phase lb study

INTRODUCTION: Epigenetic modifications play an important role in progression and development of resistance in (V600E)BRAF positive metastatic melanoma. Therefore, we hypothesized that the action of vemurafenib (BRAF inhibitor) can be made more effective by combining with low dose decitabine (a DNA m...

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Udgivet i:Oncotarget
Main Authors: Zakharia, Yousef, Monga, Varun, Swami, Umang, Bossler, Aaron D., Freesmeier, Michele, Frees, Melanie, Khan, Mirza, Frydenlund, Noah, Srikantha, Rithu, Vanneste, Marion, Henry, Michael, Milhem, Mohammed
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Clinical Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687680/
https://ncbi.nlm.nih.gov/pubmed/29179510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21269
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