Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

[Image: see text] The recent discovery of allosteric modulators of the CB1 receptor including PSNCBAM-1 (4) has generated significant interest in CB1 receptor allosteric modulation. Here in the first SAR study on 4, we have designed and synthesized a series of analogs focusing on modifications at tw...

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Библиографические подробности
Главные авторы: German, Nadezhda, Decker, Ann M., Gilmour, Brian P., Gay, Elaine A., Wiley, Jenny L., Thomas, Brian F., Zhang, Yanan
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175001/
https://ncbi.nlm.nih.gov/pubmed/25162172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501042u
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