Antigen-specific inhibition of high avidity CTL target lysis by low avidity CTL via trogocytosis: a novel mechanism of immune regulation

Current vaccine conditions predominantly elicit low avidity cytotoxic T-lymphocytes (CTLs), which are non-tumor-cytolytic but indistinguishable by tetramer staining or Enzyme-Linked ImmunoSpot from high avidity CTLs. Using CTL clones of high or low avidity for melanoma antigens, we show that low avi...

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Bibliografiske detaljer
Main Authors: Chung, Brile, Stuge, Tor B., Murad, John P., Beilhack, Georg, Andersen, Emily, Armstrong, Brian D., Weber, Jeffrey S., Lee, Peter P.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174572/
https://ncbi.nlm.nih.gov/pubmed/25088413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.052
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