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Antigen-specific inhibition of high avidity CTL target lysis by low avidity CTL via trogocytosis: a novel mechanism of immune regulation
Current vaccine conditions predominantly elicit low avidity cytotoxic T-lymphocytes (CTLs), which are non-tumor-cytolytic but indistinguishable by tetramer staining or Enzyme-Linked ImmunoSpot from high avidity CTLs. Using CTL clones of high or low avidity for melanoma antigens, we show that low avi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4174572/ https://ncbi.nlm.nih.gov/pubmed/25088413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.052 |
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