Long-Term Reduction of Jaundice in Gunn Rats by Nonviral Liver-Targeted Delivery of Sleeping Beauty Transposon

Asialoglycoprotein receptor (ASGPR)-mediated endocytosis has been used to target genes to hepatocytes in vivo. However, the level and duration of transgene expression have been low because of lysosomal translocation and degradation of the DNA and lack of its integration into the host genome. In this...

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Main Authors: Wang, Xia, Sarkar, Debi P., Mani, Prashant, Steer, Clifford J., Chen, Yong, Guha, Chandan, Chandrasekhar, Voshavar, Chaudhuri, Arabinda, Roy-Chowdhury, Namita, Kren, Betsy T., Roy-Chowdhury, Jayanta
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174336/
https://ncbi.nlm.nih.gov/pubmed/19585550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23060
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