Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler–Najjar syndrome type I with a chimeric oligonucleotide

Crigler–Najjar syndrome type I is characterized by unconjugated hyperbilirubinemia resulting from an autosomal recessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity. The enzyme is essential for glucuronidation and biliary excretion of bilirubin, and its absence can...

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Detalhes bibliográficos
Main Authors: Kren, Betsy T., Parashar, Bhupesh, Bandyopadhyay, Paramita, Chowdhury, Namita Roy, Chowdhury, Jayanta Roy, Steer, Clifford J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17891/
https://ncbi.nlm.nih.gov/pubmed/10468611
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