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Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler–Najjar syndrome type I with a chimeric oligonucleotide

Crigler–Najjar syndrome type I is characterized by unconjugated hyperbilirubinemia resulting from an autosomal recessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity. The enzyme is essential for glucuronidation and biliary excretion of bilirubin, and its absence can...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kren, Betsy T., Parashar, Bhupesh, Bandyopadhyay, Paramita, Chowdhury, Namita Roy, Chowdhury, Jayanta Roy, Steer, Clifford J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17891/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468611/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10349
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