Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler–Najjar syndrome type I with a chimeric oligonucleotide

Crigler–Najjar syndrome type I is characterized by unconjugated hyperbilirubinemia resulting from an autosomal recessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity. The enzyme is essential for glucuronidation and biliary excretion of bilirubin, and its absence can...

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Detaylı Bibliyografya
Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Kren, Betsy T., Parashar, Bhupesh, Bandyopadhyay, Paramita, Chowdhury, Namita Roy, Chowdhury, Jayanta Roy, Steer, Clifford J.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 1999
Konular:	Biological Sciences
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17891/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10349
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Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler–Najjar syndrome type I with a chimeric oligonucleotide

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