Origin Replication Complex Binding, Nucleosome Depletion Patterns, and a Primary Sequence Motif Can Predict Origins of Replication in a Genome with Epigenetic Centromeres

Origins of DNA replication are key genetic elements, yet their identification remains elusive in most organisms. In previous work, we found that centromeres contain origins of replication (ORIs) that are determined epigenetically in the pathogenic yeast Candida albicans. In this study, we used origi...

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Hauptverfasser: Tsai, Hung-Ji, Baller, Joshua A., Liachko, Ivan, Koren, Amnon, Burrack, Laura S., Hickman, Meleah A., Thevandavakkam, Mathuravani A., Rusche, Laura N., Berman, Judith
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Microbiology 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173791/
https://ncbi.nlm.nih.gov/pubmed/25182328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01703-14
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