Inhibition of DNA Topoisomerase II Selectively Reduces the Threat of Tumorigenicity Following Induced Pluripotent Stem Cell-Based Myocardial Therapy

The advent of induced pluripotent stem cell (iPSC) technology creates new opportunities for transplant-based therapeutic strategies. The potential for clinical translation is currently hindered by the risk of dysregulated cell growth. Pluripotent stem cells reprogrammed by three-factor (Sox2, Klf, a...

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Autori principali: Wyles, Saranya P., Yamada, Satsuki, Oommen, Saji, Maleszewski, Joseph J., Beraldi, Rosanna, Martinez-Fernandez, Almudena, Terzic, Andre, Nelson, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2014
Soggetti:
Original Research Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172559/
https://ncbi.nlm.nih.gov/pubmed/25036735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0259
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