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The transcriptional regulator Aire co-opts the repressive ATF7ip-MBD1 complex for induction of immune tolerance
The maintenance of immune tolerance requires the deletion of self-reactive T cells in the thymus. The expression of tissue-specific antigen genes (TSAs) by thymic epithelial cells is critical for this process and depends on the activity of the Autoimmune Regulator (Aire) protein, however, the molecu...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172453/ https://ncbi.nlm.nih.gov/pubmed/24464130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2820 |
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