Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

PURPOSE: Glioblastoma is refractory to conventional therapies. The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. These proteins recently emerged as important therapeutic targets in NUT midline carcinom...

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Bibliografiske detaljer
Main Authors: Cheng, Zhixiang, Gong, Yuanying, Ma, Yufang, Lu, Kaihua, Lu, Xiang, Pierce, Larry A., Thompson, Reid C., Muller, Susanne, Knapp, Stefan, Wang, Jialiang
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172367/
https://ncbi.nlm.nih.gov/pubmed/23403638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3066
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