Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

PURPOSE: Glioblastoma is refractory to conventional therapies. The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. These proteins recently emerged as important therapeutic targets in NUT midline carcinom...

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Detalhes bibliográficos
Main Authors: Cheng, Zhixiang, Gong, Yuanying, Ma, Yufang, Lu, Kaihua, Lu, Xiang, Pierce, Larry A., Thompson, Reid C., Muller, Susanne, Knapp, Stefan, Wang, Jialiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172367/
https://ncbi.nlm.nih.gov/pubmed/23403638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3066
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