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Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

PURPOSE: Glioblastoma is refractory to conventional therapies. The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. These proteins recently emerged as important therapeutic targets in NUT midline carcinom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Zhixiang, Gong, Yuanying, Ma, Yufang, Lu, Kaihua, Lu, Xiang, Pierce, Larry A., Thompson, Reid C., Muller, Susanne, Knapp, Stefan, Wang, Jialiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172367/
https://ncbi.nlm.nih.gov/pubmed/23403638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3066
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