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CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity
The Cullin 9 (CUL9) gene encodes a putative E3 ligase that localizes in the cytoplasm. Cul9 null mice develop spontaneous tumors in multiple organs, however either the cellular or molecular mechanisms of CUL9 in tumor suppression are currently not known. We show here that deletion of Cul9 leads to a...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172312/ https://ncbi.nlm.nih.gov/pubmed/24793696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.046 |
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