The 3M complex maintains microtubule and genome integrity

CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The mechanism underlying the function of the three 3M genes in development is not known. We found that OBSL1 and CCDC8 form a complex with CUL7 and regulate the level and centrosomal...

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Detalhes bibliográficos
Main Authors: Yan, Jun, Yan, Feng, Li, Zhijun, Sinnott, Becky, Cappell, Kathryn M., Yu, Yanbao, Mo, Jinyao, Duncan, Joseph A., Chen, Xian, Cormier-Daire, Valerie, Whitehurst, Angelique W., Xiong, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165194/
https://ncbi.nlm.nih.gov/pubmed/24793695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.047
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