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Small Molecule Inhibition of the Na(+)/H(+) Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

[Image: see text] We have identified a series of small molecules that bind to the canonical peptide binding groove of the PDZ1 domain of NHERF1 and effectively compete with the association of the C-terminus of the parathyroid hormone 1 receptor (PTH1R). Employing nuclear magnetic resonance and molec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fitzpatrick, Jeremy M., Pellegrini, Maria, Cushing, Patrick R., Mierke, Dale F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172209/
https://ncbi.nlm.nih.gov/pubmed/25171053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500368k
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