Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Once-daily s.c. administration of either human parathyroid hormone (PTH)-(1–84) or recombinant human PTH-(1–34) provides for dramatic increases in bone mass in women with postmenopausal osteoporosis. We initiated a program to discover orally bioavailable small molecule equivalents of these peptides....

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Autors principals: Carter, Percy H., Liu, Rui-Qin, Foster, William R., Tamasi, Joseph A., Tebben, Andrew J., Favata, Margaret, Staal, Ada, Cvijic, Mary Ellen, French, Michele H., Dell, Vanessa, Apanovitch, Donald, Lei, Ming, Zhao, Qihong, Cunningham, Mark, Decicco, Carl P., Trzaskos, James M., Feyen, Jean H. M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Physical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871873/
https://ncbi.nlm.nih.gov/pubmed/17428923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605125104
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