Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Once-daily s.c. administration of either human parathyroid hormone (PTH)-(1–84) or recombinant human PTH-(1–34) provides for dramatic increases in bone mass in women with postmenopausal osteoporosis. We initiated a program to discover orally bioavailable small molecule equivalents of these peptides....

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Carter, Percy H., Liu, Rui-Qin, Foster, William R., Tamasi, Joseph A., Tebben, Andrew J., Favata, Margaret, Staal, Ada, Cvijic, Mary Ellen, French, Michele H., Dell, Vanessa, Apanovitch, Donald, Lei, Ming, Zhao, Qihong, Cunningham, Mark, Decicco, Carl P., Trzaskos, James M., Feyen, Jean H. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871873/
https://ncbi.nlm.nih.gov/pubmed/17428923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605125104
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky