Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Once-daily s.c. administration of either human parathyroid hormone (PTH)-(1–84) or recombinant human PTH-(1–34) provides for dramatic increases in bone mass in women with postmenopausal osteoporosis. We initiated a program to discover orally bioavailable small molecule equivalents of these peptides....

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Bibliografiset tiedot
Päätekijät: Carter, Percy H., Liu, Rui-Qin, Foster, William R., Tamasi, Joseph A., Tebben, Andrew J., Favata, Margaret, Staal, Ada, Cvijic, Mary Ellen, French, Michele H., Dell, Vanessa, Apanovitch, Donald, Lei, Ming, Zhao, Qihong, Cunningham, Mark, Decicco, Carl P., Trzaskos, James M., Feyen, Jean H. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2007
Aiheet:
Physical Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871873/
https://ncbi.nlm.nih.gov/pubmed/17428923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605125104
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