Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Once-daily s.c. administration of either human parathyroid hormone (PTH)-(1–84) or recombinant human PTH-(1–34) provides for dramatic increases in bone mass in women with postmenopausal osteoporosis. We initiated a program to discover orally bioavailable small molecule equivalents of these peptides....

Full description

Saved in:
Bibliographic Details
Main Authors: Carter, Percy H., Liu, Rui-Qin, Foster, William R., Tamasi, Joseph A., Tebben, Andrew J., Favata, Margaret, Staal, Ada, Cvijic, Mary Ellen, French, Michele H., Dell, Vanessa, Apanovitch, Donald, Lei, Ming, Zhao, Qihong, Cunningham, Mark, Decicco, Carl P., Trzaskos, James M., Feyen, Jean H. M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871873/
https://ncbi.nlm.nih.gov/pubmed/17428923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605125104
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items