Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model

BACKGROUND: The highly selective α(2)-adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown. METHODS:...

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Detalles Bibliográficos
Autores principales: Ezzati, M, Broad, K, Kawano, G, Faulkner, S, Hassell, J, Fleiss, B, Gressens, P, Fierens, I, Rostami, J, Maze, M, Sleigh, J W, Anderson, B, Sanders, R D, Robertson, N J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
Materias:
Emergency Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171780/
https://ncbi.nlm.nih.gov/pubmed/24724965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/aas.12318
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