Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A(2)α via AKT in prostate cancer cells

Aberrant increase in pAKT, due to a gain-of-function mutation of PI3K or loss-of-function mutation or deletion of PTEN, occurs in prostate cancer and is associated with poor patient prognosis. Cytosolic phospholipase A(2)α (cPLA(2)α) is a lipid modifying enzyme by catalyzing the hydrolysis of membra...

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Main Authors: Vignarajan, Soma, Xie, Chanlu, Yao, Mu, Sun, Yuting, Simanainen, Ulla, Sved, Paul, Liu, Tao, Dong, Qihan
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171630/
https://ncbi.nlm.nih.gov/pubmed/25026288
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