Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A(2)α via AKT in prostate cancer cells

Aberrant increase in pAKT, due to a gain-of-function mutation of PI3K or loss-of-function mutation or deletion of PTEN, occurs in prostate cancer and is associated with poor patient prognosis. Cytosolic phospholipase A(2)α (cPLA(2)α) is a lipid modifying enzyme by catalyzing the hydrolysis of membra...

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Bibliographic Details
Main Authors:	Vignarajan, Soma, Xie, Chanlu, Yao, Mu, Sun, Yuting, Simanainen, Ulla, Sved, Paul, Liu, Tao, Dong, Qihan
Format:	Artigo
Language:	Inglês
Published:	Impact Journals LLC 2014
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4171630/ https://ncbi.nlm.nih.gov/pubmed/25026288
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Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A(2)α via AKT in prostate cancer cells

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