Targeting cytosolic phospholipase A(2) α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation

A constitutive activation of protein kinase B (AKT) in a hyper-phosphorylated status at Ser(473) is one of the hallmarks of anti-EGFR therapy-resistant colorectal cancer (CRC). The aim of this study was to examine the role of cytosolic phospholipase A(2)α (cPLA(2)α) on AKT phosphorylation at Ser(473...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zheng, Zhong, He, Xiangyi, Xie, Chanlu, Hua, Sheng, Li, Jianfang, Wang, Tingfeng, Yao, Mu, Vignarajan, Soma, Teng, Ying, Hejazi, Leila, Liu, Bingya, Dong, Qihan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322978/
https://ncbi.nlm.nih.gov/pubmed/25365190
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