AKT regulates NPM dependent ARF localization and p53(mut) stability in tumors

Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of...

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Bibliografiske detaljer
Main Authors: Hamilton, Garth, Abraham, Aswin G., Morton, Jennifer, Sampson, Oliver, Pefani, Dafni E., Khoronenkova, Svetlana, Grawenda, Anna, Papaspyropoulos, Angelos, Jamieson, Nigel, McKay, Colin, Sansom, Owen, Dianov, Grigory L., O'Neill, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171619/
https://ncbi.nlm.nih.gov/pubmed/25071014
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