Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, colony formation, and increased rates of apoptosis i...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Sharma, Namit, Everingham, Stephanie, Zeng, Li-Fan, Zhang, Zhong-Yin, Kapur, Reuben, Craig, Andrew W.B.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171618/
https://ncbi.nlm.nih.gov/pubmed/25026279
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki