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Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19
The Fc receptor (FcγRIIb) inhibits B cell responses when coengaged with B cell receptor (BCR), and has become a target for new autoimmune disease therapeutics. For example, BCR and FcγRIIb coengagement via the Fc-engineered anti-CD19 XmAb5871 suppresses humoral immune responses. We now assess effect...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4171032/ https://ncbi.nlm.nih.gov/pubmed/24828435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28841 |
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