Pronounced Effects of HERG-Blockers E-4031 and Erythromycin on APD, Spatial APD Dispersion and Triangulation in Transgenic Long-QT Type 1 Rabbits

BACKGROUND: Prolongation of action potential duration (APD), increased spatial APD dispersion, and triangulation are major factors promoting drug-induced ventricular arrhythmia. Preclinical identification of HERG/I(Kr)-blocking drugs and their pro-arrhythmic potential, however, remains a challenge....

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Hlavní autoři: Ziupa, David, Beck, Julia, Franke, Gerlind, Perez Feliz, Stefanie, Hartmann, Maximilian, Koren, Gideon, Zehender, Manfred, Bode, Christoph, Brunner, Michael, Odening, Katja E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170956/
https://ncbi.nlm.nih.gov/pubmed/25244401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107210
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