Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential d...

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Main Authors: Biermann, Jürgen, Wu, Kezhong, Odening, Katja E., Asbach, Stefan, Koren, Gideon, Peng, Xuwen, Zehender, Manfred, Bode, Christoph, Brunner, Michael
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997896/
https://ncbi.nlm.nih.gov/pubmed/20959120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.10.016
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