Transgenic LQT2, LQT5, and LQT2‐5 rabbit models with decreased repolarisation reserve for prediction of drug‐induced ventricular arrhythmias

BACKGROUND AND PURPOSE: Reliable prediction of pro‐arrhythmic side effects of novel drug candidates is still a major challenge. Although drug‐induced pro‐arrhythmia occurs primarily in patients with pre‐existing repolarisation disturbances, healthy animals are employed for pro‐arrhythmia testing. To...

詳細記述

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書誌詳細
出版年:Br J Pharmacol
主要な著者: Hornyik, Tibor, Castiglione, Alessandro, Franke, Gerlind, Perez‐Feliz, Stefanie, Major, Péter, Hiripi, László, Koren, Gideon, Bősze, Zsuzsanna, Varró, András, Zehender, Manfred, Brunner, Michael, Bode, Christoph, Baczkó, István, Odening, Katja E.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
Research Papers
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393202/
https://ncbi.nlm.nih.gov/pubmed/32436214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15098
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