Transgenic LQT2, LQT5, and LQT2‐5 rabbit models with decreased repolarisation reserve for prediction of drug‐induced ventricular arrhythmias

BACKGROUND AND PURPOSE: Reliable prediction of pro‐arrhythmic side effects of novel drug candidates is still a major challenge. Although drug‐induced pro‐arrhythmia occurs primarily in patients with pre‐existing repolarisation disturbances, healthy animals are employed for pro‐arrhythmia testing. To...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Hornyik, Tibor, Castiglione, Alessandro, Franke, Gerlind, Perez‐Feliz, Stefanie, Major, Péter, Hiripi, László, Koren, Gideon, Bősze, Zsuzsanna, Varró, András, Zehender, Manfred, Brunner, Michael, Bode, Christoph, Baczkó, István, Odening, Katja E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393202/
https://ncbi.nlm.nih.gov/pubmed/32436214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15098
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