Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction

We have generated transgenic rabbits lacking cardiac slow delayed-rectifier K(+) current [I(Ks); long QT syndrome type 1 (LQT1)] or rapidly activating delayed-rectifier K(+) current [I(Kr); long QT syndrome type 2 (LQT2)]. Rabbits with either genotype have prolonged action potential duration and QT...

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Main Authors: Odening, Katja E., Kirk, Malcolm, Brunner, Michael, Ziv, Ohad, Lorvidhaya, Peem, Liu, Gong Xin, Schofield, Lorraine, Chaves, Leonard, Peng, Xuwen, Zehender, Manfred, Choi, Bum-Rak, Koren, Gideon
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944497/
https://ncbi.nlm.nih.gov/pubmed/20581090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00074.2010
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