Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action

Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and they can interact with topoisomerase I. We hypot...

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Autori principali: Dudás, József, Bocsi, József, Fullár, Alexandra, Baghy, Kornélia, Füle, Tibor, Kudaibergenova, Saule, Kovalszky, Ilona
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170749/
https://ncbi.nlm.nih.gov/pubmed/25309924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/765794
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