Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action

Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and they can interact with topoisomerase I. We hypot...

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Detalhes bibliográficos
Main Authors: Dudás, József, Bocsi, József, Fullár, Alexandra, Baghy, Kornélia, Füle, Tibor, Kudaibergenova, Saule, Kovalszky, Ilona
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170749/
https://ncbi.nlm.nih.gov/pubmed/25309924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/765794
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