Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition

Pancreatic endocrine tumors (PETs) are characterised by an indolent behaviour in terms of tumor growth. However, most patients display metastasis at diagnosis and no cure is currently available. Since the PI3K/AKT/mTOR axis is deregulated in PETs, the mTOR inhibitor RAD001 represents the first line...

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Main Authors: Passacantilli, Ilaria, Capurso, Gabriele, Archibugi, Livia, Calabretta, Sara, Caldarola, Sara, Loreni, Fabrizio, Fave, Gianfranco Delle, Sette, Claudio
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170632/
https://ncbi.nlm.nih.gov/pubmed/25026292
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