Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in loss of ARID1A-protein expression and frequently co-occur with PI3K/AKT-pathway activating mechanisms. The aim of this study w...

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Autori principali: Samartzis, Eleftherios P, Gutsche, Katrin, Dedes, Konstantin J, Fink, Daniel, Stucki, Manuel, Imesch, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170604/
https://ncbi.nlm.nih.gov/pubmed/24979463
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