SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition

Upregulation of the PI3K pathway has been implicated in the initiation and progression of several types of cancer, including renal cell carcinoma (RCC). Although several targeted therapies have been developed for RCC, durable and complete responses are exceptional. Thus, advanced RCC remains a letha...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Terzo, Esteban A., Lim, Aaron R., Chytil, Anna, Chiang, Yun Chen, Farmer, Leah, Gessner, Kathryn H., Walker, Cheryl Lyn, Jansen, Valerie M., Rathmell, W. Kimryn
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363018/
https://ncbi.nlm.nih.gov/pubmed/30774762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26567
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