Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

AIM OF THE STUDY: To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory treatment. METHODS: MRN expression was exami...

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Hauptverfasser: Koppensteiner, Romana, Samartzis, Eleftherios P., Noske, Aurelia, von Teichman, Adriana, Dedes, Ioannis, Gwerder, Myriam, Imesch, Patrick, Ikenberg, Kristian, Moch, Holger, Fink, Daniel, Stucki, Manuel, Dedes, Konstantin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057395/
https://ncbi.nlm.nih.gov/pubmed/24927325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100041
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