Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer

BACKGROUND: BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins, e.g. MR...

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Vydáno v:BMC Cancer
Hlavní autoři: Brandt, Simone, Samartzis, Eleftherios P., Zimmermann, Anne-Katrin, Fink, Daniel, Moch, Holger, Noske, Aurelia, Dedes, Konstantin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223425/
https://ncbi.nlm.nih.gov/pubmed/28073364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3026-2
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