Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts

The molecular co-chaperone CDC37 is over-expressed in hepatocellular carcinoma (HCC) cells, where it functions with HSP90 to regulate the activity of protein kinases in multiple oncogenic signaling pathways that contribute towards hepatocarcinogenesis. Disruption of these signaling pathways via inhi...

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Bibliografiska uppgifter
Huvudupphovsmän: Wei, Wei, Wu, Song, Wang, Xiaolin, Sun, Chris Kin-Wai, Yang, Xiaoyang, Yan, Xinrui, Chua, Mei-Sze, So, Samuel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2014
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170594/
https://ncbi.nlm.nih.gov/pubmed/25051375
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