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Structural analyses of Ca(2+)/CaM interaction with Na(V) channel C-termini reveal mechanisms of calcium-dependent regulation
Ca(2+) regulates voltage-gated Na(+) (Na(V)) channels and perturbed Ca(2+) regulation of Na(V) function is associated with epilepsy syndromes, autism, and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered by a lack of structural information and competing models fo...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170523/ https://ncbi.nlm.nih.gov/pubmed/25232683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5896 |
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